On a study of the effect of CBD on programmed cell death in breast cancer cell lines found that CBD induced programmed cell death, independent of the CB1, CB2, or
vanilloid receptors. CBD ingibited the survival of both estrogen receptor-positive and estrogen receptor-negative breast cancer cell lines, inducing apoptosis in a
concentration-dependent manner while having little effetc on nontumorigenic mammary cells. CBD and other chemicals found in cannabis have an anti-tumor effect and could be
used to improve standard treatments.
Cannabinoids may be promising tools in combination therapy for breast and prostate cancer, due to their direct antitumor effects, their ability to improve the effectiveness of conventional antitumor drugs, and their usefulness as a treatment to reduce pain.
CBD successfully stopped cancer cells in multiple different cervical cancer cells, other studies also show the antitumor effect of cannabinoids (CBD and THC) in preclinical models of breast cancer. Cannabis has been cultivated by man since Neolithic times. It was used, among others for fiber and rope production, recreational purposes and as an excellent therapeutic agent. The isolation and characterization of the structure of one of the main active ingredients of cannabis - tetrahydrocannabinol as well the discovery of its cannabinoid binding receptors CB1 and CB2, has been a milestone in the study of the possibilities of the uses of Cannabis sativa and related products in modern medicine. Many scientific studies indicate the potential use of cannabinoids in the fight against cancer. Experiments carried out on cell lines in vitro and on animal models in vivo have shown that phytocannabinoids, endocannabinoids, synthetic cannabinoids and their analogues can lead to inhibition of the growth of many tumor types, exerting cytostatic and cytotoxic neoplastic effect on cells thereby negatively influencing neo-angiogenesis and the ability of cells to metastasize.
The main molecular mechanism leading to inhibition of proliferation of cancer cells by cannabinoids is apoptosis. Studies have shown, however, that the process of apoptosis in cells, treated with recannabinoids, is a consequence of induction of endoplasmic reticulum stress and autophagy. On the other hand, in the cellular context and dosage dependence, cannabinoids may enhance the proliferation of tumor cells by suppressing the immune system or by activating mitogenic factors. Although cannabinoids exhibit a broad variety of anticarcinogenic effects, their potential use in cancer therapy is limited by their psychoactive effects. Here we evaluated the impact of cannabidiol, a plant-derived non-psychoactive cannabinoid, on cancer cell invasion.
Using Matrigel invasion assays we found a cannabidiol-driven impaired invasion of human cervical cancer (HeLa, C33A) and human lung cancer cells (A549) that was reversed by antagonists to both CB(1) and CB(2) receptors as well as to transient receptor potential vanilloid 1 (TRPV1). The decrease of invasion by cannabidiol appeared concomitantly with upregulation of tissue inhibitor of matrix metalloproteinases-1 (TIMP-1). Knockdown of cannabidiol-induced TIMP-1 expression by siRNA led to a reversal of the cannabidiol-elicited decrease in tumor cell invasiveness, implying a causal link between the TIMP-1-upregulating and anti-invasive action of cannabidiol. P38 and p42/44 mitogen-activated protein kinases were identified as upstream targets conferring TIMP-1 induction and subsequent decreased invasiveness. Additionally, in vivo studies in thymic-aplastic nude mice revealed a significant inhibition of A549 lung metastasis in cannabidiol-treated animals as compared to vehicle-treated controls. Altogether, these findings provide a novel mechanism underlying the anti-invasive action of cannabidiol and imply its use as a therapeutic option for the treatment of highly invasive cancers.
Invasion and metastasis of aggressive breast cancer cells is the final and fatal step during cancer progression, and is the least understood genetically. Clinically, there are still limited therapeutic interventions for aggressive and metastatic breast cancers available. Clearly, effective and nontoxic therapies are urgently required. Id-1, an inhibitor of basic helix-loop-helix transcription factors, has recently been shown to be a key regulator of the metastatic potential of breast and additional cancers. Using a mouse model, we previously determined that metastatic breast cancer cells became significantly less invasive in vitro and less metastatic in vivo when Id-1 was down-regulated by stable transduction with antisense Id-1. It is not possible at this point, however, to use antisense technology to reduce Id-1 expression in patients with metastatic breast cancer. Here, we report that cannabidiol (CBD), a cannabinoid with a low-toxicity profile, could down-regulate Id-1 expression in aggressive human breast cancer cells. The CBD concentrations effective at inhibiting Id-1 expression correlated with those used to inhibit the proliferative and invasive phenotype of breast cancer cells. CBD was able to inhibit Id-1 expression at the mRNA and protein level in a concentration-dependent fashion. These effects seemed to occur as the result of an inhibition of the Id-1 gene at the promoter level. Importantly, CBD did not inhibit invasiveness in cells that ectopically expressed Id-1. In conclusion, CBD represents the first nontoxic exogenous agent that can significantly decrease Id-1 expression in mevitastatic breast cancer cells leading to the down-regulation of tumor aggressiveness. Leading from this there is a an obvious need to further explore cannabinoid associated molecular pathways making it possible to develop safe therapeutic drug agents for patients in the future.
Due to its anti-inflammatory role, CBD is a very promising therapeutic agent for a variety of inflammatory and pain-associated disorders. Research around the compounds in
this plant for inflammation reduction is especially important because inflammation is basically a bodily state that correlates to many life-threatening diseases. Many people’s
lives can be saved through proper prevention measures, and for those individuals who are deep into their issues with inflammation, they may be able to turn things around before
it is too late. Before we dive into the research around CBD and Hemp and Inflammation, I think it’s appropriate to actually define what inflammation truly is. Armed with this
basic understanding, you’ll more firmly grasp the results of the studies I’m going to present to you today. Inflammation is a bodily response to harmful stimuli.
Many things can cause this response in your body, which is why inflammation is more of what I would consider a “warning sign” rather than a disease itself. Like I mentioned earlier, because it is a warning sign it typically correlates with many different diseases in humans.
The major easy-to-spot signs that you have inflammation issues are: pain, swelling, soreness, fatigue, itchy skin, redness, heat, and even gut issues like Ulcerative Colitis, IBS, and diarrhea.
Inflammation is basically a generic response to a threat to your health. Your body activates your immune system as you try to fight off the “attacker.” Unfortunately for most people, their habits are what causes the inflammation in the first place. They are attacking themselves! Bad habits like poor diet, micronutrient deficiencies, excess stress, and constant exposure to endocrine disrupting chemicals like those found in plastics, smog in the air, and even many foods, are constantly bombarding our bodies every single day, and unless you are aware of them, you’re essentially just reinforcing their attack on your body.
It’s no wonder inflammation is such a common thing these days, and autoimmune diseases are increasing in number every single year. We are quite literally enabling this to happen to ourselves. And unless we wake up to this reality, it will continue to happen. We seem to live in an era where we stumble from one health crisis to the next. Along with the antibiotic-resistant bacteria and opioid epidemics, we also have the chronic inflammation and chronic inflammatory disease crisis. There has been a significant change in our diets, lifestyle, and food supply, and the result is a decline in general health.
Inflammation is our body’s natural response to harmful cells and pathogens. It acts as a protective measure against the initial damage suffered by the immune system. The condition is divided into Acute & Chronic categories. Acute inflammation is caused by injured tissues or bacterial pathogens whereas chronic inflammation is caused by consistent acute inflammations or foreign agents. We need a new way to fight the problem as pharmaceuticals are not getting the job done. Could CBD be our secret weapon against inflammation? Traditional Inflammation Treatments & Their Side Effects.
Inflammation is attributed to a variety of medical conditions with heart disease and cancer among the most serious. It is also associated with Bone diseases such as osteoporosis Metabolic disorder complications such as type 2 diabetes, Chronic inflammatory diseases such as COPD and IBD, Neurological disorders such as Alzheimer’s and Parkinson’s.
Statistics surrounding our health in the United States make for grim reading:
8% of the population has diabetes. 43 million Americans are afflicted with arthritis and joint disease. Over 5 million Americans have Alzheimer’s disease.The rate of obesity in American adults is 66%. Johns Hopkins School of Medicine believes that at the current rate of increase, every American adult will be obese by 2048!
The list goes on and on, and the range of pharmaceutical treatments for inflammation is not getting any better!
Non-steroidal Anti-inflammatory Drugs (NSAIDs) are the most common pharmaceutical treatment for inflammation. They include: Aspirin, Ibuprofen, Celecoxib,Oxaprozin, Piroxicam.
One of the main issues with NSAIDs such as Aspirin and Ibuprofen, in particular, is that people pop them like candy without realizing the formidable range of side effects such as: Vomiting, Nausea, Constipation, Diarrhea RashDizziness & Drowsiness.
More serious side effects include possible liver and kidney failure, ulcers and prolonged bleeding after sustaining an injury or after surgery. Even more worryingly, NSAIDs increase the risk of potentially fatal strokes and heart attacks. Given the problems associated with these pharmaceutical drugs, it is hardly surprising to learn that patients are desperately seeking alternatives such as CBD for their inflammation worries.
How Can CBD Help With Inflammation?
The simple answer is to change our diets and increase our Omega 3 index levels. However, the solution isn’t as basic as that for an increasing percentage of Americans. CBD is long associated with anti-inflammatory and immunosuppressive qualities, and the clamor for this cannabinoid has increased significantly since the FDA approved it as a food supplement. The two main cannabinoid receptors in your nervous system are CB1 and CB2. While THC is more effective when dealing with CB1 (controls perception, mood, sleep, memory, and appetite), CBD has a greater impact on the CB2 receptor (affects the immune system). Since inflammation is an ‘immune response,’ it is important for any compound to focus on the CB2 receptor to reduce inflammation. While CBD is not the only known cannabis compound to activate the CB2 receptor, it is the most abundant.
The Research on CBD
Arguably the most exciting studies relating to CBD and inflammation have shown that it is the strongest of all anti-inflammatory options, beating off stiff competition from Omega-3, vitamin C, and various antioxidants.
Several compounds within marijuana help reduce inflammation, but CBD is arguably the most effective. One significant study was performed on mice at the Imperial College London and showed that CBD possessed powerful anti-inflammatory capabilities. The researchers found that when the mice received 5mg/kg of CBD, their inflammation was reduced by up to 50%. Oddly enough, the anti-inflammatory effects of CBD were negligible when the mice received 25mg/kg. Does CBD oil help with autoimmune disease? Overwhelmingly, the clinical and anecdotal evidence suggests that CBD oil can help manage the inflammatory symptoms caused by autoimmune diseases. As anecdotal accounts relating to some of the most prevalent autoimmune conditions, and how cannabidiol may help. We also delve into what an autoimmune disease is, so we can better understand why cannabidiol is being used by consumers to help manage symptoms. The body of evidence that cannabinoids may help people with an Autoimmune disease is growing. Recent studies show that THC and CBD cannabinoids can reduce inflammation, prevent the spread of pathogens, and boost the immune system.
A staggering 50 million Americans have been diagnosed with an autoimmune disease like Rheumatoid Arthritis, Lupus, Celiac, Multiple Sclerosis, Type-1 Diabetes and more. In fact, it’s estimated that there are between 80 and 100 different types.
An autoimmune disease is a condition where the immune system launches an attack on the body. Instead of targeting bacteria and viruses (pathogens), the immune system thinks healthy cells are foreign invaders… and goes to war.
Nobody is exactly sure what causes this to happen, but inflammation is a common characteristic of autoimmune disease. Other symptoms include redness, heat, pain, swelling, and dysfunction.
Autoimmune diseases can be incredibly painful and debilitating. Most treatment options come with a manuscript of horrible side effects.
For years, thousands of people with autoimmune diseases have quietly promoted cannabis as a safe, effective treatment option in dealing with the pain that comes with autoimmune diseases. But today, with our ability to isolate certain cannabinoids and terpenes, pain reduction is just the tip of the iceberg.
In recent years, scientists have been seeking to understand how cannabis works to alleviate autoimmune diseases symptoms. THC and CBD can both reduce inflammation. But no one has really understood how cannabis can calm the immune response and act as an anti-inflammatory That’s changing. Research from scientists at the University of South Carolina shows that cannabis can reduce inflammation related to autoimmune disease. The study, published in The Journal of Biochemistry Research found that THC actually affected the participants DNA through something called epigenomes Epigenomes are like light switches, they turn genes on and off.
The study showed that THC influenced a group of proteins called histones, which triggered certain inflammation producing genes to slow down or turn off.
In another study published in the online journal Future Medicinal Chemistry researchers found that THC can stimulate immune system cell apoptosis. Apoptosis is when a cell dies. This is a natural function in the body to maintain balance and homeostasis, but in people with an autoimmune disease immune cells stay active and continue fighting healthy cells instead of dying off naturally.
Neurodegenerative disorders are on the rise in most industrialized nations. In the United States alone nearly 5.4 million people suffer from Alzheimer's disease, while
roughly 500,000 suffer from Parkinson's. As the American popupation ages, these numbers are only going to increase. A Large percentage of people have direct experience with
neurodegenerative disorders either through their own diagnosis or through the diagnosis of loved ones. Brain disorders such Parkinson's, Huntington's or Alzheimer's have some
of the highest disease burdens. Disease burden, according to the World Health Organization (WHO), characterizes the number of healthy years wich are affected by disability
and death. Neurodegenerative disorders are considerably more burdern some because they not only affect on families. The disease burden for neurodegenerative disorders has
been calculated to be more significant than even cancer.
Because the rates of these diseases are likely to continue to increase, the race is on to find effective treatment options. The options available today are limited in scope, and are typically costly. They also have significant side effects. Many side-effects for the most common drugs associated with Parkinson's and Alzheimer's cause vomiting, nausea, digestive issues, and decreased appetite, just to name a few. As scientific research expand into the realm of medical marijuana, and its various beneficial components, there us beginning to be significant excitement surrounding the treatment possibilities for neurodegenerative disorders with cannabidiol oil (CBD OIL).
At the moment, results are preliminary but studies into CBD OIL treament for neurodegenerative diseases such as Huntington's Parkinson's and Alzheimer's is overwhelming positive. Not only does CBD treament target some of the most debilitating symptoms of these diseases but CBD oil also seems to suggest little to no side effect risk. For many people managing their symptoms or for family members assisting their loved ones, CBD is offering a rary of hope for a variety of increasingly severe neurological disease.
How does CBD treat NeurodegenerativeDisorders?
Cannabidiol and THC have been found to have anti-inflammatory characteristics specically in cases of chronic brain inflammation. They have also been found to target oxidative-stress and cellular dysfunction. They also have an extremely powerful effect on the overall health of the endocannabinoid system and neurotrophic(or brain cell) support. CBD was found to prevent toxic effects of neurotransmitter glutamate and radical oxygen species (ROS) in the brain, thus preventing brain cell death.
According to at least one recent study, there seems to be preliminary evidence suggesting that CBD specifically slows down brain aging, a primary suspect in many neurodegenerative diseases. CBD acts in some experimental models as an anti-inflammatory, anticonvulsant, anti-oxidant, anti-emetic, anxiolytic and antipsychotic agent, and is therefore a potential medicine for the treatment of neuroinflammation, epilepsy, oxidative injury, vomiting and nausea, anxiety and schizophrenia, respectively. The neuroprotective potential of CBD, based on the combination of its anti-inflammatory and anti-oxidant properties, is of particular interest and is presently under intense preclinical research in numerous neurodegenerative disorders. In fact, CBD combined with Δ(9)-tetrahydrocannabinol is already under clinical evaluation in patients with Huntington's disease to determine its potential as a disease-modifying therapy. The neuroprotective properties of CBD do not appear to be exerted by the activation of key targets within the endocannabinoid system for plant-derived cannabinoids like (9)-tetrahydrocannabinol, i.e. CB(1) and CB(2) receptors, as CBD has negligible activity at these cannabinoid receptors, although certain activity at the CB(2) receptor has been documented in specific pathological conditions (i.e. damage of immature brain). Within the endocannabinoid system, CBD has been shown to have an inhibitory effect on the inactivation of endocannabinoids (i.e. inhibition of FAAH enzyme), thereby enhancing the action of these endogenous molecules on cannabinoid receptors, which is also noted in certain pathological conditions. CBD acts not only through the endocannabinoid system, but also causes direct or indirect activation of metabotropic receptors for serotonin or adenosine, and can target nuclear receptors of the PPAR family and also ion channels.
As with most current research into CBD benefits, more is desperately needed. As CBD becomes more widely accepted and the legal barriers are removed, scientific study is becoming more viable. Research into CBD treament for neurodegenerative disorders is in its relatively early stages, but the vast majority of it is pointing to positive results. As more large-scale clinical trials are completed, the results should continue to demonstrate effective and powerful treatment of neurodegenerative diseases with CBD OIL.
Multiple sclerosis is a disorder of the nervous system, where the covering that insulates nerve cells complexes in the brain and spinal cord are damaged, which results in
resulting in dysfunction communication and feedback between neurons. MS symptoms and conditions are expressed physically and mentally. Cannabis derivatives may relieve
symptoms in multiple sclerosis patients.
In early stage MS, symptoms may come and go, with an onward progression to more advanced conditions, that permanently damage neurons. Mainstream medical science has yet to fully describe the mechanism by which the coating, the sheath deteriorates, however it is certain that metabolic dysfunction is responsible. The myelin coating about the nerve fibers is composed of protein, which degenerates or the repair mechanism is interrupted. Dysfunctional myelin production and maintenance can be caused by a number of mechanisms theoretically.
Autoimmune disorders play an important role in MS, where an overly active immune system's cells actually consume myelin. Implicated in the overactive immune response is the myriad of unnatural chemicals and biological agents that are introduced into the body which overwhelm or confuse the immune system. Agents include GMO, herbicides, pesticides, vaccines, chemical additives, bacterial, fungal and viral invasion, compromised, damaged gut, intestinal flora among other causes.
The components of medical marijuana, specifically THC and CBD affect cells throughout the body and specifically nerve cells, to normalize their electrical activity and improve biofeedback, where overactive nerve cells stop firing excessively and randomly Symptoms of MS: Brain, Balance, speech, coordination, tremor issues, Motor Weak muscles, paralysis, vision, bladder, bowel issues, Sensory, Aberrant sensation, numbness, pins and needles pain.
WHY MS PATIENTS AND DOCTORS TURN TO CANNABIS MEDS
Orthodox pharmacological treatment of MS does not offer a cure. Treatments are aimed at symptoms such as; spasticity, pain, fatigue, bladder problems and depression.
MS pharmaceutical drugs have very limited effectiveness and display many adverse side effects, which has led to alternate approaches. Currently, cannabis based medicines have rapidly risen in popularity, its availability as a legal medicine in many states. Largely from word of mouth, and testimonials and discussion groups on the internet, medical marijuana has perhaps become the therapy of choice of MS.
Patients with multiple sclerosis (MS) usually experience a range of impairments, of which muscle spasticity is often prominent and disabling. Following completion of a double-blind, placebo-controlled trial of a cannabis-based medicinal extract (CBME) in the symptomatic treatment of MS, patients were given the option to enter a long-term follow-up trial to determine whether benefits seen following CBME might be maintained over many months of treatment. Sativex® is one of the first cannabis-based medicines to undergo conventional clinical development and to be approved in canada as a prescription medicine. It is an oromucosal spray that allows flexible, individualised dosing. Patients self titrate their overall dose and pattern of dosing according to their response to and tolerance of the medicine. This usually results in the administration of ∼ 8 – 12 sprays/day. Each spray delivers tetrahydrocannabinol 2.7 mg and cannabidiol 2.5 mg, giving an approximate average dose of tetrahydrocannabinol 22 – 32 mg/day and cannabidiol 20 – 30 mg/day. Development has concentrated on the treatment of symptoms of multiple sclerosis, notably spasticity and neuropathic pain, as well as the treatment of neuropathic pain of other aetiologies. Positive results in placebo-controlled trials of the use of Sativex as an add-on therapy in these indications demonstrate that Sativex is efficacious and well tolerated in the treatment of these symptoms. Sativex has been approved for use in neuropathic pain due to multiple sclerosis in Canada. If ongoing studies replicate the results already observed, further approvals for the treatment of spasticity in multiple sclerosis and for neuropathic pain are likely in other countries.
The majority of patients with multiple sclerosis (MS) develop troublesome lower urinary tract symptoms (LUTS). Anecdotal reports suggest that cannabis may alleviate LUTS, and cannabinoid receptors in the bladder and nervous system are potential pharmacological targets. Everyone’s treatment plan differs. As always, consider discussing all medications (and herbs) that you may be taking with your doctor when determining the best way to treat your condition. Though they may be as knowledgeable about how to treat Multiple Sclerosis with cannabis as the MS patient themselves, an open discussion on the drug’s effects and progress with other medications will help safeguard from any negative interactions.
For those with MS, it may not be clear cut how exactly cannabis can help yet. But the research will help. With more attention and publicity to the experience of those with MS, like celebrity Montel Williams who have used cannabis to treat their symptoms, more options and guidance may be available on the effects of cannabis on MS.
That’s enough to keep up the high hopes.
CBD, a non-psychoactive constituent of the Cannabis sativa plant, has been receiving growing attention for its anti-psychotic-like properties. CBD is a potential treatment for psychosis.
CBD improves the symptoms of schizophrenia. Evidence suggests that CBD can ameliorate positive and negative symptoms of schizophrenia. Behavioral and neurochemical models suggest that CBD has a pharmacological profile similar to that of atypical anti-psychotic drugs and a clinical trial reported that this cannabinoid is a well-tolerated alternative treatment for schizophrenia. Researchers first discovered that CBD could provide new kinds of symptom relief for schizophrenic individuals by examining what science has uncovered about the chemical so far. To get a sense of CBD’s impact on cognitive function in relation to schizophrenia, Dr. Katrina Green, Professor Nadia Solowij, and Wollongong Ph.D. candidate Ashleigh Osborne conducted a detailed review of 27 extant studies on the chemical and uncovered some “fascinating insights” about its potential therapeutic value. in illnesses associated with cognitive impairment, including Alzheimer’s disease, as well as neurological and neuro-inflammatory disorders,” including hepatic encephalopathy, meningitis, sepsis, and cerebral malaria.
Green, who led the review, also noted that CBD may well be capable of reducing cognitive impairment that has been associated with THC, the main psychoactive component of cannabis, which has previously shown a potential to aggravate aspects of schizophrenia, anxiety, and other mental disorders. On the other hand, the antipsychotic effects of CBD are similar to a common antipsychotic medication, amisulpride. However, the adverse effects commonly seen in some antipsychotics, such as weight gain, movement disorders, and increased levels of prolactin, are not observed with the use of CBD.
It should be noted that the use of CBD oil for Schizophrenia, Biopolar, Anxiety and other mental illness’s are only in the early stages. So far, studies have indicated that there is an antipsychotic and anxiolytic effect created by CBD, which can be useful in the management of schizophrenia and related mental illnesses. It is also important to discuss the increased dopamine is associated with schizophrenia.
Anandamide, an endogenous cannabinoid, is found to neutralize the increased levels of dopamine. According to research studies, CBD oil increases the production of anandamide, this stops some of the activity of dopamine, which contributes to the symptoms associated with schizophrenia.
The research surrounding CDB as a treatment for schizophrenia is extremely promising. CBD oil for schizophrenia could be a major game changer.
While we must take care not to portray CBD oil for schizophrenia as a cure for very serious and debilitating cognitive disorders like schizophrenia, it is an area into which we must continue to look. Scientists should conduct further research into the possibilities. In the meantime, however, it can be encouraging to look at the anecdotal evidence we have available.
Approximately 50 million people worldwide live with epilepsy, a neurological condition that involves recurring seizures. This makes it one of the most common neurological
diseases globally. This condition prevents or makes daily tasks difficult such as caring for children, preparing food, driving, or maintaining a job and career. In severe
cases, the patient’s quality of life can become so low that he or she experiences clinical depression or anxiety in anticipation of the next seizure.
Epileptic seizures are caused by irregular electrical discharges, or misfiring, among brain cells. The misfiring results in convulsions of the body, loss of consciousness, and sometimes severely altered senses. Epilepsy itself may be caused by head injuries, hormonal imbalance, or viruses. But it is often stated that the cause of epilepsy is simply unknown.
Traditionally, epilepsy patients are prescribed one or more anticonvulsants. These pharmaceutical drugs in this category include valproic acid, phenytoin, primidone, clonazepam, phenobarbital and ethosuximide. The problem with anticonvulsants is they are often relatively ineffective and come with a number of negative side effects. It is those two factors that have driven many patients to seek cannabis oil as a solution where normal pharmaceutical therapies have failed or provided too much suffering. These side effects can include headaches, nausea, loss of hair, liver failure, depression, double vision, weight gain, slurring of speech, irritability, sleep disturbances, sedations, impotence, and mood disturbances.
Exogenous cannabinoids can limit seizures and neurodegeneration, and their actions are largely mimicked by endogenous cannabinoids (endocannabinoids). Endocannabinoids are mobilized by epileptiform activity and in turn influence this activity by inhibiting synaptic transmission; both excitatory and some inhibitory synapses can be suppressed, leading to potentially complex outcomes. Moreover, the endocannabinoid system is not a fixed entity, and its strength can be enhanced or reduced. Endocannabinoids and their receptors are altered by epileptic seizures in ways that can reduce the efficacy of both exogenous and endogenous cannabinoids in sometimes unexpected ways. The inhibition of epilepsy by CBD may therefore be caused by various mechanisms, although the detailed mechanisms of CBD actions have not yet been well defined. In most studies, trial doses of CBD were 2-5 mg/kg/day. Several such studies have shown that CBD does have efficacy for treatment of epilepsy. Reported adverse effects of CBD were mostly mild, including drowsiness, diarrhea, and decreased appetite. Severe adverse reactions requiring treatment, such as status epilepticus, have also been reported but it is not clear that this is related to CBD.
Furthermore, many previous studies have been limited by an open-label or survey design. In future, double-blind, controlled trials are required and the use of CBD to treat other neurological problems should also be investigated. In a survey including parents of children with treatment-resistant epilepsy, 84% of parents reported a reduction in their child’s seizure frequency while taking CBD. FDA approves first marijuana-based epilepsy drug.
The FDA approved Epidiolex, a CBD, to treat two rare forms of epilepsy: Lennox-Gastaut syndrome and Dravet syndrome.
The U.S. Food and Drug Administration approved the use of a drug derived from marijuana for the first time on Monday june 25 2018 , giving the go ahead to treat two rare forms of epilepsy with the compound cannabidiol, also known as CBD, found in hemp and marijuana. Epidiolex, a form of cannabidiol, will be legally used to treat Lennox-Gastaut syndrome and Dravet syndrome, two serious and rare kinds of epilepsy. Epidiolex is the first approved treatment for Dravet syndrome, according to the FDA. Though CBD is extracted from marijuana sativa plants, it does not produce the high typically associated with marijuana because it does not contain the psychoactive ingredient THC. Instead, CBD is often used in oil form as a way to relieve anxiety without the high.
"This approval serves as a reminder that advancing sound development programs that properly evaluate active ingredients contained in marijuana can lead to important medical therapies", FDA Commissioner Scott Gottlieb said in a statement. Epidiolex was effective in reducing the frequency of seizures in patients with the two syndromes in clinical trials. Since both Lennox-Gastaut syndrome and Dravet synonym appear in early childhood, Epidiolex is legal in treatment for patients two-year-old and above. We are moving forward with the benefits of cbd oil, their will be more to come!!!
How Cannabidiol(CBD) works for treating Anxiety.
While we don't normally think of anxiety as desirable, it's actually a critical adaptive response that can help us cope with threats to us (or a loved one's) sagety and welfare. These responses help us recognize and avert potential threats; they can also help motivate us to take action to better our situation. However, when we don't manage these natural responses effectively, they can become maladaptive and impact our work and relationships. This can lead to clinically diagnosable anxiety-related disorders. This disorders affect a huge segment of our population 40 million adults (18%) in the United States age 18 and older. In response, Big Pharma has developed numeros drugs to treat anxiety- related disorders, from selective serotonin reuptake inhibitors(SSRISs) like Prozac and Zoloft to tranquilizers(the most popular class being benzodiazepines such as Valium and Xanax) While this Drugs can be effective for many patients, some don't respond favorably Certain patients don't see much improvement, or they can't tolerate the side effects. Moreover, tranquilizers like Valium and Xanax can be highly addictive. Clearly, alter treaments are warranted.
Could cannabidioil(CBD), the most prominent non-intoxicating constituent in cannabis, provide a viable alternative for currently available anxiety medication? Quiet possible!!! In recent years, CBD has generated a tremendous amount of interest among consumers, Clinicians, and scientist. Why? Not only does evidence suggest CBD counteracts many of THC's adverse effects, but numerous animal studies and accumulating evidence from human experimental, clinical, and epidemiological studies suggest CBD had powerful anti-anxiety properties. Cannabidiol reduces anxiety in both healthy individuals and patients with social anxiety disorder. Administered acutely(as needed) it appears safe, well-tolarated, and may be beneficial to treat a number of anxiety-related disorders, like:
• Post-traumatic stress disorder
• General anxiety disorder
• Panic disorder
• Social anxiety disorder
• Obsessive-compulsive disorder
• Several studies point to the potential benefits of CBD for anxiety. For generalized anxiety, the National Institute on Drug Abuse says that CBD has been shown to reduce stress in animal studies. Study subjects were observed as having lower behavioral signs of anxiety. Their physiological symptoms of anxiety, like increased heart rate, also improved.
Studies have also shown some benefits for other forms of anxiety, such as social anxiety disorder (SAD) and post-traumatic stress disorder (PTSD). CBD may also help treat anxiety-induced insomnia. In 2011, a human study on CBD and its effects on SAD was published in the Journal of Psychopharmacology. Participants were given either an oral dose of 400 milligrams of CBD or a placebo. The results showed that those who took the CBD dose experienced overall reduced anxiety levels.
On the other hand, a 2017 comprehensive review of CBD studies in psychiatric disorders found inconclusive results. According to the authors, there isn’t enough evidence to claim CBD as a treatment for depression. However, the authors do note positive results for anxiety disorders. Based on their review, more human tests are needed to better understand how it works, what ideal dosages should be, and if there are potential side effects or hazards.
CBD has also been studied in other neurological disorders.
• A 2016 study found some antipsychotic benefits of CBD in schizophrenia. The authors indicated a preference for CBD over antipsychotic drugs, which are known to cause significant debilitating side effects. Right now researchers are on the process of doing more studies of CBD as a treatment for anxiety to adverse the effects. We will keep you posted!!!!
Studies suggest that cannabinoids may be a new class of drugs for the treatment of chronic pain.
CBD significantly decreased chronic inflammatory and neuropathic pain in rodents.
Cannabidiol, especially in a combination with THC, shows promising results for the treatment of postoperative pain, chronic pain associated with multiple sclerosis, cancer, rheumatoid arthritis, and neuropathic pain.
Sativex, a combination of CBD and THC as a sublingual spray, is effective in treating neuropathic pain in patients with multiple sclerosis and in cancer patients with advanced pain.
Sativex, a combination of CBD and THC as a sublingual spray, is effective in treating neuropathic pain in patients with multiple sclerosis and in cancer patients with advanced pain. Studies show that CBD and opioids act together to relieve pain.
Benefits of CBD On Chronic Pain:
1. Anti Inflammatory
Inflammation is the health buzz-word of the day. And for good reason — chronic inflammation (defined as swelling that extends beyond the initial healing process needed to address an acute illness or wound) causes pain and eventually damages tissue. Long-term use of pharmaceutical grade NSAIDs and over-the-counter pain killers have side effects on the liver, kidney, and stomach. For short-term usage, they are effective and helpful, but demand for long-term solutions that do not damage the body are in high demand. CBD fits the bill. It only has one major side effect — too much will make you sleepy. So play with your dose and find the right balance for you. A little less in the daytime, and a little more at night if sleep is also a problem.
2. The Muscles Relax
Have you ever been sitting on the couch thinking, “I should be doing yoga, but it just hurts too much!” It’s easy for others to casually suggest that yoga would heal your body, not realizing that the challenge is bigger than just motivation or time. High levels of pain make stretching, and sometimes even breathing, extremely difficult. CBD’s pain-relieving, and anti-inflammatory effects make yoga easier! I don’t know about you, but if something doesn’t hurt, I’m a lot more likely to do it. For conditions like Ankylosing Spondylitis, movement is essential: it slows progression of arthritic fusion.
3. Sleep Heals
Chronic pain fries your nerves by triggering a “fight or flight” response in your nervous system. This reaction should be reserved for danger, but since pain is a constant, internal trigger, your body feels threatened all the time. This imbalance hits sleep hard. If your body always feels as though it’s in danger, how can you ever rest? The worst part is this: if you’ve lost the ability to rest, your body stays sick. CBD is neuroprotective and calming, helping you regain much needed sleep.
4. Anxiety Relief
A frizzled nervous system translates emotionally into anxiety. Tired and wired, and constantly on high alert, each small disturbance of peace feels like a freight train bulldozing through your living room. CBD soothes your nervous system, effectively taking the edge off of anxiety.
Post traumatic stress disorder is associated with the re-experience of a traumatic event caused by an external trigger. Triggers cause a fight or flight cascade, often resulting in shaking, hyper-vigilance, and a feeling of being disconnected, terrified, or potentially self-destructive. What many people don’t realize is that living with chronic pain is a recurring trauma. You wake up in the morning scared that you’ll hurt all day. You dread going to bed at night from fear of waking up in agony. Each day is unpredictable. You become unreliable, maybe even reclusive. CBD helps PTSD in a similar way that it helps anxiety. It nourishes an overwrought nervous system, and takes the edge off of daily fear.
6. Uplifts Depression
Chronic pain is a major cause for depression. It’s hard to get out of bed in the morning and face another day of strain. Adding CBD into a regimen of fish oil or krill oil, B vitamins, and lemon balm can be a game-changer. • CBD oil is being vaporized, ingested, used as a tincture, and applied topically worldwide, as pain sufferers online and in brick-and-mortar stores carefully search for the best CBD oil for pain relief. People are self-dosing CBD for back pain, joint inflammation, pain from accidents and chronic conditions; and many other symptoms, as well.
So, the million dollar question is: does CBD oil work for chronic pain management? The short answer is that CBD is currently considered an investigative analgesic, meaning that it’s in a state of scientific limbo, so to speak. There is enough promising evidence from existing and past studies to continue research around the compound, but there is not enough definitive evidence for physicians to begin confidently prescribing it in masse starting tomorrow. When you add CBD’s status as an investigative analgesic to the overwhelming amount of anecdotal (self-reported) success stories surrounding CBD, you can get an idea of where we’re currently at in terms of classifying cannabidiol as a pain relief option.
The best way to answer this question for yourself is to speak with your doctor and see if trying CBD as an adjunctive (additional) pain treatment is appropriate for you, given your unique health circumstances. If your physician approves, try CBD for yourself and see how you react to it; we’d love to hear from you and get a first hand account of what your experience is like.
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